list of synergistic drug combinations

To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points. Abstract: The invention relates to a synergistic antibiotic composition useful for the treatment of respiratory, gastrointestinal or urinary infections and septicaemia of domestic animals. Chem. 9-11 September 2010 Abstract Synergistic drug combinations are a promising strategy and tend to improve therapeutically relevant selectivity . The dose reduction index (DRI) measures to which extent the concentration of a drug in combination can be reduced at a given inhibition level X compared with the concentration of an individual drug alone. In addition to synergism, other terms are used to define toxicologic interactions. Description: Contain analgesics in combination with other analgesics, or with other substances that enhance the analgesic effect (such as caffeine) or induce sleep or other desired effects. “Analysis of DrugCell mechanisms leads directly to the design of synergistic drug combinations, which we validate systematically by combinatorial CRISPR, drug-drug screening in … First, drug combinations expand the spectrum of antibiotics for a … Not all drug interactions are bad. Multifunctional nanoparticles for targeting the tumor microenvironment to improve synergistic drug combinations and cancer treatment effects M. Chen, C. Lai, Y. Lin, C. Huang and Y. Lin, J. Cocaine and alcohol use is one of the most common combinations among drug users because of the powerful high that both substances produce. Drug combinations having synergistic effect . In silico strategies to classify synergistic vs. antagonistic drug pairs is more efficient than experimental strategies. Drug combinations play an important role in therapeutics due to its better efficacy and reduced toxicity. Network target for screening synergistic drug combinations with application to traditional Chinese medicine Shao Li*, Bo Zhang, Ningbo Zhang From The 4th International Conference on Computational Systems Biology (ISB 2010) Suzhou, P. R. China. In the synergism matrices, the green to red scale is used to indicate antagonist combinations (green) and synergistic combinations (red). Drug combinations have been used for treatment of a variety of diseases including infectious diseases. Alternatively, drug interactions result from competition for a single receptor or signaling pathway. A clear definition of required pharmacokinetics and pharmacodynamics properties will also help with the design of drug regimens for dosing anti-malarial drug combinations . The rarity of self-crosses in our screens and the disparate drug mechanisms or indications underlying each of the example combinations point to the synergies being largely explained by multi-target interactions, as is the case for synergistic responses in theoretical studies17, 24. Includes narcotic analgesic combinations. The study objective was to: 1) screen FDA‐approved drugs for their ability to inhibit Ca 2+ ‐mobilization in uterine myometrial (UT‐myo) cells, 2) omit hit‐drugs that display cytotoxicity and lack uterine‐selectivity, 3) identify synergistic combinations of hit‐drugs and 4) evaluate ex vivo tocolytic efficacy and potency of … We developed a sensitive drug interaction classification assay and used it to find 38 synergistic drug pairs, of which only 1 (Terbinafine–Rapamycin) had been previously reported (Lehar et al, 2007). In this study, we systematically explored drug combinations to evaluate specific and promiscuous models of drug synergy. SLAS Discov. Combinatorial drug therapy can improve the therapeutic effect and reduce the corresponding adverse events. Additive Effect - This action occurs when the combined effect of two or more chemicals is equal to the sum of the effect of each agents given alone (they do not interact in a direct way); for example:. Hence, the synergistic pairs will require further investigations in in vivo models to fully evaluate the possibility of transferring them into clinic. A major aim of synergistic drug combinations is to reduce the dose of a drug, thereby reducing toxicity while maintaining therapeutic efficacy. We have previously used median-effect analysis in vitro to define both synergistic and antagonistic drug combinations which may be of value in management of human disease. Antagonistic drug interactions occur when taking one drug partially or completely negates the effect of another drug a patient is taking. Since validating drug combinations via direct screening is prohibitively expensive due to combinatorial explosion, recent approaches have applied machine learning to identify synergistic combinations for cancer. Drug antagonism, in contrast, is often undesirable, but could be useful in selecting against drug resistant mutations . Drug interactions may lead to an increase or decrease in the beneficial or the adverse effects of the given drugs. The information of drug combinations was retrieved from public drug databases TTD and DCDB. Screening of a sparse number of doses per drug allows to screen large numbers of drug pairs, but complicates statistical assessment of synergy. Confirmation of the most potential combination has been confirmed in vivo in xenografted mice. The interactions between these drug combinations were assessed by a dose matrix approach. These studies extend our findings in defined prostate cancer cell lines. Synergistic drug combinations for infectious diseases. However, most of the developed methods have been applied only to cancer therapies. Through systematic screening of two-component combinations, fungistatic and analgesic agents can show synergistic activity against drug-resistant Candida albicans without significant cytotoxicity. Antiviral drug development for coronavirus disease 2019 (COVID-19) is occurring at an unprecedented pace, yet there are still limited therapeutic opti… Some medications may be better absorbed if taken with food or may have more favorable blood levels if taken with other medications that affect metabolic enzymes. Only these have pharmacodynamic synergistic or additive effect were compiled in this study. Frequently, these combinations have demonstrated synergistic activity both in vitro and in animal models before being used therapeutically. Combinations of nitazoxanide with remdesivir, amodiaquine, or umifenovir exhibited significant synergy against SARS-CoV-2. Analgesic combinations, including narcotic analgesic combinations. 2019 , 24, 653 – 668 . Synergistic combinations are abundant in our model Figure 2 shows the distribution of percentage of solved cases being synergistic for all 33,798 drug combinations we have studied. Results: Irinotecan induced in vivo the activation of … This portal enables the identification of synergistic drug combinations through harmonization and unified computational analysis. Since SynToxProfiler uses the normalized volume-based scoring for synergy, efficacy and toxicity levels (see Methods and S1 Text), the SynToxProfiler framework can be easily utilized to prioritize synergistic drug combinations with high selective efficacy also for higher-order combination screening (3 or more drugs). Drug combinations have the potential to improve efficacy while limiting toxicity. Mater. 2 + 2 = 4. Remdesivir combined with hydroxychloroquine or other lysosomotropic drugs resulted in strong antagonism. 1. United States Patent 4650790 . In the synergistic response, the applied antibiotics work together to produce an effect more potent than if each antibiotic were applied singly. Doctors may use certain antagonist drugs to their advantage. The black cells show additive combinations. Table S2 Pharmacology information of 350 unique drugs in the drug combination list. Drug combinations may exhibit synergistic or antagonistic effects. Microtubulin binding agents such as docetaxel have significant preclinical and clinical activity in the treatment of hormone-refractory prostate cancer. Cancer drug combinations to evaluate specific and promiscuous models of drug pairs is more efficient experimental... For dosing anti-malarial drug combinations to evaluate specific and promiscuous models of drug synergy or antagonism, contrast... Against SARS-CoV-2 analgesic agents can show synergistic activity both in vitro and in animal models before being used.. 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